Careers

Scientist, Vector Expression Technologies

Encoded Therapeutics Inc. is a biotechnology company advancing precision medicines for a broad range of genetic disorders. Our mission is to unlock new opportunities for viral gene therapy through genomics-driven discovery. We focus on delivering life-changing advances for individuals with genetic disorders not addressable with current approaches. For more information, please visit www.Encoded.com.

We are recruiting a Scientist to lead exploration and development of next generation rAAV expression technologies within the Process Development department. This is a rare opportunity to enter an emerging field, in a company committed to developing first-rate platform capabilities. By enhancing our ability to manufacture rAAV vectors, our work will directly contribute to enabling gene therapies in broader and more challenging indications. The successful candidate will work across multiple projects, and should expect a fast-paced, dynamic environment.

Responsibilities

• Develop next-generation rAAV expression technologies with a goal to better-supply large market needs, or improve product quality
• Champion cross-functional study of rAAV expression biology in collaboration with internal molecular biology, bioinformatics, vector core, and analytical development groups. Initiatives may incorporate NGS or CRISPR technologies, proteomics, identification of novel approaches, or validation of approaches from literature.
• Design of plasmids and expression constructs utilizing novel genetic elements and/or novel configurations.
• Hands-on execution of small-scale expression studies, with support from incumbent Research Associates.
• May evaluate external technologies for potential incorporation into Encoded’s platform
• May propose and/or develop novel analytical methods to support unique PD needs.
• Contribute to development of long-term PD platform strategy, in collaboration with Process Development leadership, and Encoded’s CTO
• Collaborate across broader PD&AD departments for incorporation of promising technologies into platform manufacturing process. (i.e., optimization, scalability, and integration with other next-gen process improvements)
• May originate and manage external contract research projects, and capital equipment purchases
• May include approximately 10-20% remote work, with flexibility based on project needs and group development.
• Generate intellectual property and contribute to FTO analysis and patent applications for process technologies

Requirements

• PhD related to molecular biology, virology, immunology, or closely related discipline, with 2+ years industry experience preferred
• OR Master’s degree related to molecular biology, virology, immunology, or closely related discipline and 5-10 years of industry experience
• Skilled at molecular cloning, design of gene expression cassettes, and plasmid design
• Ability to conceptualize and execute research plans based on long-term platform objectives.
• Mathematical ability to perform relevant data analysis and statistics, including skill with MS Excel.
• Enthusiasm for collaborative work in a dynamic environment, plus individual accountability within areas of responsibility
• Strong verbal and written skills are required, as well as effective interpersonal, technical, and troubleshooting skills

Preferred Qualifications

• Prior experience designing plasmid vectors and/or cell lines for virus, VLP, or gene therapy vector expression
• Experience performing rAAV expression, large-scale transfection, and/or baculovirus TGE
• Working knowledge of conventional cell line development platforms and familiarity with requirements for GMP clinical manufacturing
• Prior experience with IP generation and patent filings
• Prior engagement in LIMS initiatives

Benefits

• Comprehensive benefits package, including competitive employer premium contributions
• Meaningful stock option grants
• PTO, sick time and holiday pay
• Generous Parental Leave program
• Pre-tax medical and dependent care programs
• STD, LTD, Life and AD&D
• Professional development opportunities
• Team-building events
• Fully stocked kitchen
• Purple Tie dry cleaning service
• Fitness center

Encoded is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Encoded is committed to the principle of equal employment opportunity for all employees and to providing employees with a work environment free of discrimination and harassment. All employment decisions at Encoded are based on business needs, job requirements and individual qualifications, without regard to race, religion or belief, color, national origin, gender, status as a protected veteran, status as an individual with a disability, or any other status protected by the laws or regulations in the location in which we operate. Encoded will not tolerate discrimination or harassment based on any of these characteristics. Encoded encourages applicants of all ages.

If you need assistance or an accommodation due to a disability, you may call us at +1 650-491-0272.

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