Preclinical – Encoded Therapeutics

Senior Research Associate – Immunology, Translational Sciences

Encoded Therapeutics Inc. is a biotechnology company advancing precision medicines for a broad range of genetic disorders. Our mission is to unlock new opportunities for viral gene therapy through genomics-driven discovery. We focus on delivering life-changing advances for individuals with genetic disorders not addressable with current approaches. This is a unique opportunity to work at the intersection of genomics and therapeutics and participate in the development of a diverse therapeutic pipeline driven by transformative core technologies. For more information, please visit www.Encoded.com.

We are recruiting an experienced motivated Senior Research Associate to join our growing Immunology – Translational Sciences team. The Immunology team is developing methods to understand AAV biology in large animal models to contribute to nonclinical development of gene therapy products for neurological indications.

Responsibilities

Develop, perform and analyze AAV and transgene immunogenicity assays in various matrices using plate-based immunoassay methods
Design and conduct plate-based ELISAs, electrochemiluminescence (ECL)- based (e.g., MSD platform) and/or bead-based (e.g., Luminex multiplex platform) immunoassays
Understand flow cytometry principles and conduct well-designed experiments
Perform immunoassay method development efforts, organize well-designed experiments, and accurately analyze and present data
Author and review standard operating protocols (SOPs) and study technical reports
Communicate results with clarity at team meetings
Engage to work collaboratively within teams to deliver exceptional results
Comply with all basic laboratory practices and safety protocols
Contribute and build to the culture of continued process involvement

Requirements

Bachelor’s degree in Biological Sciences with 5+ years of experience or Master’s degree in Biological Sciences with 3+ years of experience in the pharmaceutical industry
Background knowledge in immunology, neuroscience or gene-based therapy concepts preferred
Strong practical knowledge of protein immunogenicity method development, cut-point calculations and data analysis
Familiarity with concepts of method development, qualification and validation in accordance with regulatory guidelines is preferred
Ability to troubleshoot and interpret complex data in an independent fashion
Excellent organizational, interpersonal skills and ability to effectively communicate in a team setting
Strong analytical computation skills to analyze, graph and perform statistical analysis using Excel, GraphPad Prism, FlowJo and JMP software programs

Benefits

Comprehensive benefits package, including competitive employer premium contributions
Meaningful stock option grants
PTO, sick time and holiday pay
Generous Parental Leave program
Pre-tax medical and dependent care programs
LTD, Life and AD&D
Professional development opportunities
Team-building events
Fully stocked kitchen

Encoded is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Encoded is committed to the principle of equal employment opportunity for all employees and to providing employees with a work environment free of discrimination and harassment. All employment decisions at Encoded are based on business needs, job requirements and individual qualifications, without regard to race, religion or belief, color, national origin, gender, status as a protected veteran, status as an individual with a disability, or any other status protected by the laws or regulations in the location in which we operate. Encoded will not tolerate discrimination or harassment based on any of these characteristics. Encoded encourages applicants of all ages.

If you need assistance or an accommodation due to a disability, you may call us at +1 650-491-0272.

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Senior Scientist, Translational and Nonclinical Bioanalytical Sciences

Encoded Therapeutics Inc. is a biotechnology company advancing precision medicines for pediatric CNS disorders. Our mission is to unlock new opportunities for viral gene therapy through genomics-driven discovery. We focus on delivering life-changing advances for individuals with genetic disorders not addressable with current approaches. For more information, please visit www.Encoded.com.

Encoded is seeking a Senior Scientist of Translational and Nonclincial Bioanalytical Sciences to perform and oversee the nonclinical biodistribution and dose-determining biochemical studies in the development of gene therapy products. The successful candidate will be a scientific leader that can expand our assays and methods to develop our understanding of in vivo vector biodistribution and transgene expression profile for gene therapy product and contribute to interpretation of nonclinical pharmacology and toxicology studies to support clinical development programs.

Ideal candidate will be enthusiastic, entrepreneurial scientist motivated to shape the development of gene therapy products. As an important member of the Translation research team, this individual will be responsible for method development, sample testing, data analysis and integration of results for proof-of-concept and pivotal non-clinical studies leading to regulatory filings. Strong analytical and method development skills with ability to perform and coordinate activities both within internal teams (research groups) and external partners (large animal CROs) are required.

Responsibilities:

Contributes to the development and execution of bioanalytical studies for candidate gene therapy products, throughout the drug development lifecycle
Provide high quality analytical assessments for tissue biodistribution and mRNA expression profiles with sensitive quantitative molecular biology tools like qPCR, digital droplet (dd)PCR, RT-ddPCR and other pertinent platform technologies.
Familiar with sensitive and robust protein detection methods to detect and quantify tissue transgene protein expression profiles using biochemical methods like electrochemiluminescence (ECL)-based Immune assays on MSD platform, Luminex, mass spectrometry approaches and other technologies.
Provide molecular biology expertise in the analysis and interpretation of results to integrate with the overall nonclinical studies
Provide scientific monitoring and guidance on outsourcing studies for method transfer, troubleshooting, qualification and validation studies to support gene therapy development
Author and review method development SOPs, qualification, validation and sample testing reports for regulatory submissions
Succinctly and effectively communicate interpretations of nonclinical molecular biodistribution and biochemical studies at cross-functional meetings
Stay updated with knowledge of regulatory agency nonclinical and gene therapy regulations/guidelines, and relevant scientific literature

Requirements

PhD in Biochemistry, Molecular Biology or equivalent
5+ years experience including industry including postdoctoral work in fast-paced environments
Depth of experience in AAV gene therapy or related genetic therapies is essential.
Broad knowledge and background in central nervous systems is a plus.
Extensive knowledge in conducting molecular assays for DNA and RNA measurements with qPCR, digital droplet PCR, Reverse transcription-PCR methods in a variety of biological matrices. Familiarity with high-throughput nucleic acid purification platforms like KingFisher and sample quality systems like Bioanalyzer and TapeStation
Deep analytical abilities to analyze, graph and complete statistical analysis of large-scale data sets using Excel, JMP, GraphPad Prism software programs.
Strong bioanalytical skills and familiarity with approaches and methods to allow sensitive and robust quantitation of tissue expressed transgene protein including mass spectrometry methods
Proficiency and practical knowledge of method development, troubleshooting, qualification and validation in accordance with regulatory guidelines
Outstanding communication, presentation, and writing skills
Personnel characteristics of integrity, teamwork, and commitment to excellence to fit with Encoded core values for success

Benefits

Comprehensive benefits package, including competitive employer premium contributions
Meaningful stock option grants
PTO, sick time and holiday pay
Generous Parental Leave program
Pre-tax medical and dependent care programs
STD, LTD, Life and AD&D
Professional development opportunities
Team-building events
Fully stocked kitchen
Purple Tie dry cleaning service
Fitness center

If you need assistance or an accommodation due to a disability, you may call us at +1 650-491-0272.

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Senior Research Associate – Assay Development

We are recruiting an experienced and motivated Senior Research Associate to join our Assay Development – Translational Sciences team. The ideal candidate will bring his/her experience with assay design, development, qualification, sample testing, data analysis, and documentation, and become part of a team supporting the nonclinical development of gene therapy products for neurological indications.

Responsibilities:

Develop and qualify robust bioanalytical methods (plate-based ligand binding immunoassays and cell-based bioassay) in a variety of biological matrices to support development of gene therapy products.
Extensive knowledge and familiarity in developing and conducting ELISA-based assays on Spectramax and MSD platforms, complex cell-based assays, cytokine analysis using Luminex platform.
Analytical abilities to analyze, graph and perform statistical analysis on large-scale data sets using Excel, JMP, GraphPad Prism software programs
Perform study sample analysis and maintain complete and accurate records following record management best practices and contribute to continuing process improvement
Author and review standard operating protocols (SOPs) and technical study reports
Coordinate parallel tasks across multiple projects and plan, prioritize, and manage duties to meet departmental and organizational goals.
Promote innovation and explore novel analytical techniques or technology.

Requirements

Bachelor’s degree in Biological Sciences with 5+ years of experience or Master’s degree with 3+ years of experience in the pharmaceutical industry
Hands on experience in designing and developing bioanalytical assays for sensitive and robust quantitation of transgene protein tissue expression and complex cell-based assays
Familiar with concepts of method development, qualification, and validation in accordance with regulatory guidelines
Ability to troubleshoot and interpret complex data in an independent fashion
Excellent organizational, interpersonal skills to work effectively in a fast-paced matrixed environment
Outstanding communication, presentation and writing skills
Strong analytical computation skills to analyze, graph and perform statistical analysis using Excel and GraphPad Prism

Benefits

Comprehensive benefits package, including competitive employer premium contributions
Meaningful stock option grants
PTO, sick time and holiday pay
Generous Parental Leave program
Pre-tax medical and dependent care programs
STD, LTD, Life and AD&D
Professional development opportunities
Team-building events
Fully stocked kitchen
Purple Tie dry cleaning service
Fitness center

If you need assistance or an accommodation due to a disability, you may call us at +1 650-491-0272.

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Scientific Study Manager

Encoded is looking for an experienced and highly motivated Scientific Study Manager who will be responsible for centrally managing activities required for the effective design, execution, and completion of outsourced Good Laboratory Practices (GLP) and non-GLP primate studies to assess safety and vector biodistribution for CNS indications. The successful candidate will be an engaged member of the Translational team that will proactively manage multiple aspects of external studies, including, but not limited to, study planning and design, protocol development, study coordination and monitoring, study execution, data collection, and reporting activities. For Good Laboratory Practice (GLP)-regulated studies, the position will be responsible for GLP audits and ensuring compliance with appropriate GLP regulations.

Responsibilities:

Effectively manage all aspects of outsourced GLP and non-GLP primate studies with minimal supervision, high accuracy, and scientific integrity.
Manage progress of studies to ensure adherence to the protocol, objectives, and overall strategy.
Anticipate and efficiently resolve/troubleshoot protocol or study-related issues or discrepancies.
Monitor the execution of primate studies via on-site visits and frequent interactions via email/video conferencing.
Lead efforts to coordinate with Encoded Supply Chain and Biorepository teams to ensure timely and accurate sample shipments between internal and external collaborators.
Maintain and organize data files and reports across outsourced studies.
Utilize program management skills to develop, track, and ensure study related deliverables are achieved according to scheduled timelines.
Travel: Up to 10% domestic travel required to conduct on-site study monitoring as the designated sponsor representative.

Requirements

PhD in biology, neuroscience, or related sub-discipline with 6 or more years of pharmaceutical/biotechnology experience in large animal model preclinical toxicology and GLP-testing (21CFR, Part 58) OR
Master’s in biology, neuroscience, or related sub-discipline with 10 or more years of pharmaceutical/biotechnology experience in large animal model preclinical toxicology and GLP-testing (21CFR, Part 58)
Proven ability to work with a high level of integrity and accuracy, supported by excellent time management and organizational skills.
Strong communication and interpersonal skills (oral and written) that enable the individual to interact proactively with CROs, facilitate external meetings, and provide frequent study updates to internal teams.
Demonstrated history of working in cross-functional teams supporting safety assessments for biologics in primates.
Familiarity with multiple routes of drug administration, including brain surgical methods.
Problem solving skills, critical thinking skills, and attention to scientific detail.
Proficiency with Microsoft Office (Excel, PowerPoint, Word), GraphPad Prism, SAS JMP

Preferred Qualifications:

Experience with toxicology teams in conducting primate safety assessments for Neuroscience/ CNS indications, including investigating mechanisms of toxicity in large animal models.
Previous genetic therapy experience (e.g. Anti Sense Oligonucleotides, Cell or Gene Therapy)

Benefits

Comprehensive benefits package, including competitive employer premium contributions
Meaningful stock option grants
PTO, sick time and holiday pay
Generous Parental Leave program
Pre-tax medical and dependent care programs
STD, LTD, Life and AD&D
Professional development opportunities
Team-building events
Fully stocked kitchen
Purple Tie dry cleaning service
Fitness center

If you need assistance or an accommodation due to a disability, you may call us at +1 650-491-0272.

#LI-KM1

Director Safety Toxicology and Pathology

Encoded is seeking a Director of Safety Toxicology and Pathology to provide scientific leadership for preclinical studies in animal models in the development of cutting-edge gene therapy products for genetic pediatric neurological diseases. This position reports to the VP of Translation Sciences. The successful candidate will be an experienced leader and will serve as a toxicology and pathology expert for nonclinical gene therapy studies in preclinical models. The incumbent will contribute to the design, conduct and interpretation of nonclinical toxicology and pathology assessments for investigational studies in rodent and primate models.

This is an ideal position for a highly enthusiastic, interactive, entrepreneurial individual with demonstrated expertise in toxicology and pathology to shape the development of gene therapy products. The successful candidate will have opportunities to drive innovation and scientific excellence, make meaningful contributions to the nonclinical development of the product pipeline. This position will work in collaboration with preclinical groups and will be responsible for integrating evolving regulatory guidance and latest methodologies and scientific advances from the gene therapy and other fields towards development of gene therapy products directly delivered into the cerebrospinal fluid for neurological indications with significant unmet need.

Responsibilities:

Contributes to the characterization of general toxicology safety assessments and specialized neuronal histopathology evaluations related to preclinical studies for development of candidate gene therapy products, throughout the drug development lifecycle
Manage collaborations with Study Directors at CROs for toxicology safety assessments and specialized pathology evaluations to facilitate high quality analytical assessments as a part of the preclinical evaluations.
Lead general toxicology assessment and pathology strategy and participate in interpretation of observations with evaluating scientists and specialists, leading to well written study reports
Scientifically oversee the design, development, timely execution, analysis, interpretation and reporting of general toxicology and pathology assessments for safety studies. Drive discussions and cycles of review with evaluating scientists and specialists well written study reports. Lead investigative efforts into mechanisms of toxicity as needed.
Succinctly and effectively communicate interpretations of safety studies and pathology evaluations in writing and verbally, internally and externally, including for regulatory submissions for pre-submission (e.g. pre-IND), scientific advisory fillings and IND or CTA meeting related briefing books
Stay updated with knowledge of regulatory agency nonclinical and gene therapy regulations/guidelines, and relevant scientific literature and evaluate implications for internal studies
Hire, develop, and retain key scientific talents and provide training opportunities and mentorship to further develop a high functioning team
Drive to ensure that the activities of the team follow record management, resource management, vendor management best practices and maintain a culture of continued process improvement.

Requirements

PhD or DVM and DABT with 10+ years of relevant experience in Toxicology and Pathology in innovative CNS drug development across novel routes of drug administration.
Depth of experience in AAV gene therapy, cell-therapy or related genetic therapies is essential.
Broad knowledge and background in central nervous systems is preferred
Strong scientific background and aptitude, proactive and enthusiastic with ability to work in a matrixed, collaborative, and goal-oriented environment. Effectively and transparently manage multiple projects and resources to achieve goals
Previous experience with NOAEL determination in pivotal preclinical studies, IND, CTA and other regulatory interactions and filings is desired
Extensive knowledge and experience in conducting safety and pathology studies in small and large animal model studies
Outstanding communication, presentation, and writing skills
Personnel characteristics of integrity, teamwork, and commitment to excellence to fit with Encoded core values for success

Benefits

Comprehensive benefits package, including competitive employer premium contributions
Meaningful stock option grants
PTO, sick time and holiday pay
Generous Parental Leave program
Pre-tax medical and dependent care programs
STD, LTD, Life and AD&D
Professional development opportunities
Team-building events
Fully stocked kitchen
Purple Tie dry cleaning service
Fitness center

If you need assistance or an accommodation due to a disability, you may call us at +1 650-491-0272.

#LI-KM1

Scientist, Protein Biochemistry

At Encoded everyone works with a great deal of collaboration and responsibility. This position will require the applicant to take on personal responsibility for coordinating and executing experimental procedures across several preclinical programs. This will require organization, communication, and independent action. The preclinical team shares information and advice in order to have a trusting and respectful culture of collaboration. We offer a challenging, fast paced environment that aims to achieve big goals.

Responsibilities:

Responsible for the design, qualification and execution of a variety of protein-based analytical methods leading to selection of development candidates.
Execute on all aspects of key biochemical assays including, but not limited to: protein sample processing/analysis/quantification, cell culture and tissue processing, enrichment of subcellular compartment (such as synaptic compartment) for protein analysis, and downstream assay performance and analysis.
Analyze and interpret biochemistry and molecular biology data with methodological rigor. Select and run appropriate statistical tests.
In collaboration with colleagues across functional areas, develop and establish novel assays/procedures/approaches to meet preclinical research goals.
Coordinate sample tracking, deposition and retrieval with the biorepository and preclinical group.
Follow company guidelines and document in detail experimental procedures and results.
Present findings to interdisciplinary scientific teams to seek input on key studies and propose data-driven GO/NO GO decisions.

Requirements

PhD in biochemistry, molecular and cell biology or a related scientific discipline, preferably with at least 2 years of post-doctorate or industry experience.
Strong working knowledge and technical proficiency in protein biochemistry. Examples include ELISA/MSD-ELISA/western blotting/LICOR based protein quantification, subcellular fractionation, methods to examine/quantify post-translational modifications etc.
Demonstrated capability of generating data-driven hypotheses and designing/developing properly controlled studies/assays for hypothesis testing.
Experience with molecular biology methods (such as RNA/DNA extractions, qPCR, transfections) and molecular cloning.
Experience with biochemistry/molecular biology analysis in cell culture – primary neuronal cell culture or IPSC-derived neuronal cell culture experience is beneficial.
Highly organized, demonstrates good time management and is comfortable with multi-tasking.
Excellent analytical and critical thinking skills.
Some industry experience is strongly preferred.
Excellent oral and written communication skills.
Collaborative mindset and a willingness to work with and provide mentorship to junior RAs.
Thrives in a dynamic and fast-paced research environment.

Benefits

Comprehensive benefits package, including competitive employer premium contributions
Meaningful stock option grants
PTO, sick time and holiday pay
Generous Parental Leave program
Pre-tax medical and dependent care programs
STD, LTD, Life and AD&D
Professional development opportunities
Team-building events
Fully stocked kitchen
Purple Tie dry cleaning service
Fitness center

If you need assistance or an accommodation due to a disability, you may call us at +1 650-491-0272.

#LI-KM1

Scientist – Immunology, Translational Sciences

We are recruiting an experienced Scientist to join our growing Immunology – Translational Sciences team. The Immunology team is developing methods to understand AAV biology in large animal models to contribute to nonclinical development of gene therapy products for neurological indications.

Responsibilities:

Independently develop, perform and analyze AAV and transgene immunogenicity assays in various matrices using plate-based immunoassay methods
Design and conduct plate-based ELISAs, electrochemiluminescence (ECL)- based (e.g., MSD platform) and/or bead-based (e.g., Luminex multiplex platform) immunoassays
Understand flow cytometry principles by designing and conducting well-designed experiments
Perform immunoassay method development efforts, organize well-designed experiments, and accurately analyze and present data
Author and review standard operating protocols (SOPs) and study technical reports
Communicate results with clarity at team meetings
Engage to work collaboratively within internal cross-functional teams or oversee external CROs projects to deliver exceptional results
Comply with all basic laboratory practices and safety protocols
Contribute and build to the culture of continued process involvement

Requirements

Ph.D. in Biological Sciences with 2+ years of experience in the pharmaceutical industry
Background knowledge in immunology, neuroscience and/or gene-based therapy concepts preferred
Strong practical knowledge of protein immunogenicity method development, cut-point calculations and data analysis
Familiarity with concepts of method development, qualification and validation in accordance with regulatory guidelines is preferred
Ability to troubleshoot and interpret complex data in an independent fashion
Excellent organizational, interpersonal skills and ability to effectively communicate in a team setting
Strong analytical computation skills to analyze, graph and perform statistical analysis using Excel, GraphPad Prism, FlowJo and JMP software programs

Benefits

Comprehensive benefits package, including competitive employer premium contributions
Meaningful stock option grants
PTO, sick time and holiday pay
Generous Parental Leave program
Pre-tax medical and dependent care programs
STD, LTD, Life and AD&D
Professional development opportunities
Team-building events
Fully stocked kitchen
Purple Tie dry cleaning service
Fitness center

If you need assistance or an accommodation due to a disability, you may call us at +1 650-491-0272.

#LI-KM1

Director, In Vivo Pharmacology

Encoded Therapeutics Inc. is a biotechnology company advancing precision medicines for a broad range of genetic disorders. We are combining the precision of gene regulation with the versatility of gene therapies to create breakthrough treatments. Our mission is to unlock new opportunities for viral gene therapy through genomics-driven discovery. We focus on delivering life-changing advances for individuals with genetic disorders not addressable with current approaches. For more information, please visit www.Encoded.com.

This position will lead a small team of dedicated in vivo researchers supporting the advancement of a variety of projects within the area of monogenic neurological diseases. The Director will work in a collaborative drug discovery environment to bring forward novel gene therapies and will oversee, design and execute in vivo experiments in translational disease models, including transgenic mouse lines, to test efficacy and mechanism of action of novel gene therapy candidates. Key objectives include establishing novel in vivo translational phenotypic assays, demonstrating proof-of-concept data, enabling candidate selection, and generating high quality preclinical pharmacology packages in support of IND-enabling studies.

Responsibilities:

Strategic planning and oversight of the in vivo pharmacology evaluation of gene therapies in alignment with departmental pipeline objectives and gene therapy precedents
In vivo study design to enable clear go/no-go decision making for therapeutic programs
Identification of appropriate Contract Research Organizations for in vivo model execution including negotiating contract details

Bring forward innovative ideas, novel translational animal models and advanced technologies to support team goals. Identify opportunities and develop ideas to enhance and accelerate business processes.
Work closely with the Senior Director of In Vivo Operations to coordinate efforts across the department, including the development of SOPS and IACUC protocols
Responsible for career development of team of diverse scientists, contribute to talent strategy and provide mentorship
Contribute to nonclinical component of regulatory submissions; communicate nonclinical pharmacology findings to cross-functional teams with a balanced and clear point of view; prepare for and participate in regulatory agency interactions
Cultivate cross-functional relationships with project teams, translational medicine, biomarker teams, and disease-specific working groups to deliver novel targets, biomarkers and drug candidates
Achieve pipeline goals by managing resource allocation and oversight of progress across a diverse set of early research programs
Present scientific accomplishments internally and externally to the scientific community and discuss with key opinion leaders
Support experimental work in the lab if needed
Be recognized as a people leader on site to set and maintain a healthy culture.

Requirements

Ph.D. degree in pharmacology or neurobiology with at least 8+ years of experience in drug discovery/development in biotech or pharmaceutical industry OR experience performing progressively advanced duties at the Senior Principal Scientist / Associate Director level
Background in gene therapy or neurological disorders
Proven record in discovery and development of novel therapeutic entities including progression and screening of novel drug candidates and mechanistic studies in preclinical disease models
Experience in the development and validation of novel translational disease models
Peer reviewed publication record in relevant fields, including participation in preparation of manuscripts patents, pharmacology reports and program reviews
Team leadership and people management experience

Preferred Qualifications:

Experience in contributing to a disease area strategy creation, development and execution in a Pharma/Biotech setting

Benefits

Comprehensive benefits package, including competitive employer premium contributions
Meaningful stock option grants
PTO, sick time and holiday pay
Generous Parental Leave program
Pre-tax medical and dependent care programs
STD, LTD, Life and AD&D
Professional development opportunities
Team-building events
Fully stocked kitchen
Purple Tie dry cleaning service
Fitness center

If you need assistance or an accommodation due to a disability, you may call us at +1 650-491-0272.

#LI-KM1

Research Associate II/Senior Research Associate, Preclinical Molecular Research

Encoded Therapeutics is a therapeutics company funded by world-class healthcare investors Venrock, Arch Venture Partners, Illumina Ventures, and Matrix Capital Management. At Encoded, we are combining the precision of gene regulation with the versatility of gene therapies to create breakthrough treatments for individuals living with severe genetic diseases.

We are recruiting a highly motivated research associate to join the Molecular and Cellular Pharmacology (MCP) team within the Preclinical Research department. The role will involve contributing to therapeutic design and validation, as well as performing preclinical studies for potential disease targets. A successful candidate will work collaboratively to support molecular and cellular-based assay design, execution and analysis in order to advance pipeline programs. They will demonstrate strong technical expertise in molecular biology and biochemistry, and will contribute to multiple projects in a fast-paced and dynamic research environment. For more information, please visit www.Encoded.com.

Responsibilities:

Independently conduct and troubleshoot in vitro experiments and ex vivo assays in a Preclinical R&D environment with some guidance
Perform experiments in mammalian cell culturing with high proficiency
Demonstrate a high proficiency in molecular cloning and primer design
Demonstrate strong technical capabilities in MCP tasks including but not limited to: DNA/RNA/protein extraction from animal tissue and cultured cells, PCR, qPCR, cDNA library preparations, NGS sequencing, Western blotting, ELISA execution.
Analyze and interpret molecular, biochemical, and in vivo data with methodological rigor. Select and run appropriate statistical tests.
Participate in group meetings and present collated data packages for feedback and review
Follow company guidelines and document in detail experimental procedures, results and conclusions
Complying with all laboratory safety procedures
Perform additional tasks or assist with specialized projects as assigned or needed

Requirements

Bachelors or Masters in biology or related field, with 5+ years experience to include pharmaceutical industry, preferably in a research environment
Strong hands-on technical skills related to molecular biology required
High proficiency in molecular cloning
Experience with mammalian cell culture and aseptic technique (primary cell culture
experience beneficial) required
Experience performing DNA, RNA, and protein-based assays
Some experience with viral vectors is preferred
Proficiency with molecular biology software such as Snapgene strongly preferred
Strong computer skills with a working knowledge of Microsoft Office suite, Graphpad Prism, or other data analysis software are required
Demonstrate good time management, organizational and prioritization skills, and attention to detail
Experience following protocols and maintaining detailed laboratory notebooks
Work effectively within team-focused environment to meet objectives under time constraints
Ability to independently formulate experimental plans based on overall project goals
Exhibit willingness and flexibility to meet project timelines
Excellent oral and written communication skills
Open to working collaboratively to meet tight timelines
Thrives in a dynamic and fast-paced research environment

Benefits

Comprehensive benefits package, including competitive employer premium contributions
Meaningful stock option grants
PTO, sick time and holiday pay
Generous Parental Leave program
Pre-tax medical and dependent care programs
STD, LTD, Life and AD&D
Professional development opportunities
Team-building events
Fully stocked kitchen
Purple Tie dry cleaning service
Fitness center

If you need assistance or an accommodation due to a disability, you may call us at +1 650-491-0272.

#LI-KM1

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