Encoded Therapeutics

Associate Director, Protein Biochemistry and Assay Development

Encoded Therapeutics Inc. is a biotechnology company advancing precision medicines for a broad range of genetic disorders. Our mission is to unlock new opportunities for viral gene therapy through genomics-driven discovery. We focus on delivering life-changing advances for individuals with genetic disorders not addressable with current approaches. For more information, please visit www.Encoded.com.

Encoded is seeking a highly motivated, creative and an experienced Associate Director to be responsible for defining, growing, and managing the protein biochemistry and assay development team within the Translational Sciences group. In this role, you will be responsible for characterizing protein expression profiles from precision AAV gene therapy vectors in animal models across a variety of tissue types. You will build a biochemistry team with sensitive protein detection tools to tailor transgene protein detection for specific CNS therapeutic application with gene therapy. Encoded is developing cutting edge AAV-based gene therapies for pediatric disorders of the central nervous system. This role will work closely with the research teams in a matrixed environment and be end-to-end responsible for protein bioanalysis, including design, conduct, analyze, and report for critical animal studies to support gene therapy candidate development and pipeline progression

Workplace Model: Hybrid

Responsibilities

  • Lead all aspects of protein detection and assay development efforts to characterize AAV vector driven protein expression patterns in a dynamic, highly collaborative, and fast-paced environment.
  • Scientifically oversee the design and development of protein measurement tools to detect small amounts of therapeutic proteins or peptides in a complex matrix delivered by precision gene therapy approaches
  • Develop timely execution strategies, high-throughput testing, analysis, quantitation, interpretation, and reporting for therapeutic protein measurements in tissues and complex biological matrix across preclinical studies for advancement of CNS based gene therapy programs
  • Responsible for generation of assay controls and reagents including recombinant protein and antibody generation for nonclinical studies across preclinical programs
  • Succinctly and effectively communicate interpretations of protein biodistribution studies in writing and verbally, including for regulatory submissions.
  • Represent preclinical research as biochemistry expert and contribute content for relevant sections of regulatory submissions (including Pre-IND, IND, CTA)
  • Hire, develop, and retain key scientific talents and provide training and mentorship to build a high functioning team; balance internal vs outsourcing activities while ensuring rigor and quality of work
  • Stay updated with protein detection methodologies and quantitation tools to evaluate and adopt technologies for viable solutions for Encoded CNS gene therapy studies.
  • Drive to ensure the activities of the team follow record management, resource management and vendor management best practices and maintain a culture of continued process improvement.
  • Work effectively as a team player with scientific enthusiasm, creativity, and dedication

Requirements

  • PhD in Biochemistry or related discipline in the biological sciences
  • 5+ years of relevant work experience; industry experience and experience managing direct reports strongly preferred
  • Extensive experience in protein biochemical and biophysical techniques including western blotting methods (including Protein Simple platforms) and quantification approaches (like LICOR based methods), plate-based immunoassays (e.g. MSD, Quanterix), capillary liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) to detect specific proteins or peptides in a complex biological matrix
  • Strong practical knowledge of method development, troubleshooting and generating robust methods for protein measurements including optimizing tissue derived protein extraction methods, immunoprecipitation methods and target protein detection approaches
  • Outstanding organizational skills with the ability to work in a matrixed setting that is dynamic and fast paced
  • Independently motivated, detail-oriented, strong analytical skills and creative problem-solving ability
  • Exceptional communication skills including written and oral presentations

Preferred Qualifications

  • Familiarity with CNS, brain anatomy and neurodevelopmental diseases
  • Demonstrated experience in protein biochemistry and assay development
  • In-depth knowledge and hands-on experience working with orthogonal sensitive tools for protein detection in complex biological matrices
  • A broad understanding of drug development with past record of contributions to IND or regulatory submissions
  • Experience with AAV or viral gene therapy, CRISPR or advanced precision therapy modalities preferred

Benefits

  • Comprehensive benefits package, including competitive employer premium contributions
  • Meaningful stock option grants
  • PTO, sick time and holiday pay
  • Generous Parental Leave program
  • Pre-tax medical and dependent care programs
  • STD, LTD, Life and AD&D
  • Professional development opportunities
  • Team-building events
  • Fully stocked kitchen
  • Purple Tie dry cleaning service
  • Fitness center

Encoded is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Encoded is committed to the principle of equal employment opportunity for all employees and to providing employees with a work environment free of discrimination and harassment. All employment decisions at Encoded are based on business needs, job requirements and individual qualifications, without regard to race, religion or belief, color, national origin, gender, status as a protected veteran, status as an individual with a disability, or any other status protected by the laws or regulations in the location in which we operate. Encoded will not tolerate discrimination or harassment based on any of these characteristics. Encoded encourages applicants of all ages.

If you need assistance or an accommodation due to a disability, you may call us at +1 650-491-0272.

#LI-CD1

Scientist, Protein Biochemistry and Assay Development

Encoded Therapeutics Inc. is a biotechnology company advancing precision medicines for a broad range of genetic disorders. Our mission is to unlock new opportunities for viral gene therapy through genomics-driven discovery. We focus on delivering life-changing advances for individuals with genetic disorders not addressable with current approaches. This is a unique opportunity to work at the intersection of genomics and therapeutics and participate in the development of a diverse therapeutic pipeline driven by transformative core technologies. For more information, please visit www.Encoded.com.

We are recruiting an experienced, creative, and motivated laboratory Scientist to join our growing Protein Biochemistry and Assay Development group in Translational sciences. The ideal candidate will bring his/her experiences of protein assay design, development, qualification, sample testing, data analysis, and documentation, and become part of a team supporting the nonclinical development of gene therapy products for neurological indications.

Workplace Model: Hybrid

Responsibilities

  • Responsible for design, qualification, and execution of protein-based analytical methods to characterize therapeutic protein biodistribution from AAV vector treatments in preclinical models
  • Work independently to develop biochemical assays and optimize protein extraction procedures from a variety of tissues in mice and primates
  • Quantify target protein expression using orthogonal sensitive protein measurement methods including ELISA, MSD-based immunoassays, Western blots and LICOR quantitation, Quanterix and similar sensitive platforms.
  • Analyze, graph, and perform appropriate statistical tests using GraphPad Prism or similar software programs. Clearly interpret emerging data from rigorous methodological tools to aid in hypothesis testing
  • Perform study sample analysis and maintain complete and accurate records following record management best practices, Coordinate sample tracking, deposition, and retrieval in coordination with biorepository teams.
  • Author and review standard operating protocols (SOPs) and technical study reports
  • Coordinate parallel tasks across multiple projects and plan, prioritize, and manage duties to meet departmental and organizational goals
  • Succinctly and clearly present findings at cross-functional and interdisciplinary team meetings

Requirements

  • Ph.D. in biochemistry or related scientific discipline, 1-3 years of relevant protein biochemistry and assay development industry experience
  • Strong working knowledge and technical proficiency in protein biochemistry and assay development methods. Experience and track record of development of protein detection assays using MSD and Quanterix platforms, SDS-PAGE and Western blotting (on standard laboratory apparatus and Protein Simple platforms) together with protein quantification with LICOR technology
  • Familiarity with concepts of method development and experience generating robust protein assays for sensitive target protein detection in complex biological matrix. Track record of trouble shooting methods to generate reliable and reproducible assays
  • Excellent organizational, interpersonal skills to work effectively in a fast-paced matrixed environment; Ability to multitask and generate efficient workflows
  • Outstanding communication, presentation, and scientific writing skills
  • Strong analytical skills to analyze, graph and perform statistical analysis using Excel and GraphPad Prism

Benefits

  • Comprehensive benefits package, including competitive employer premium contributions
  • Meaningful stock option grants
  • PTO, sick time and holiday pay
  • Generous Parental Leave program
  • Pre-tax medical and dependent care programs
  • STD, LTD, Life and AD&D
  • Professional development opportunities
  • Team-building events
  • Fully stocked kitchen
  • Purple Tie dry cleaning service
  • Fitness center

Encoded is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Encoded is committed to the principle of equal employment opportunity for all employees and to providing employees with a work environment free of discrimination and harassment. All employment decisions at Encoded are based on business needs, job requirements and individual qualifications, without regard to race, religion or belief, color, national origin, gender, status as a protected veteran, status as an individual with a disability, or any other status protected by the laws or regulations in the location in which we operate. Encoded will not tolerate discrimination or harassment based on any of these characteristics. Encoded encourages applicants of all ages.

If you need assistance or an accommodation due to a disability, you may call us at +1 650-491-0272.

#LI-CD1